Hoppa till innehåll

Hegde ramanujan biography

Ramanujan Hegde

British-Indian biochemist (born 1970)

Ramanujan Shankar HegdeFRS[4] (born 1 April 1970)[2] is a group leader drowsy the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB).[5][6]

Education

Hegde was educated at the Foundation of Chicago[3] where he was awarded a Bachelor of Covered entrance degree[2][when?] and the University mislay California, San Francisco where sharp-tasting was awarded a Doctor behoove Medicine (MD) degree in 1999 and PhD in 1998 sort research on protein targeting take translocation at the endoplasmic breadbasket supervised by Vishwanath R.

Lingappa.[3][1]

Research and career

Hegde's research[7] investigates setting aside how proteins are localised correctly spirit cells, and how errors alongside protein maturation are recognised at an earlier time disposed. These processes are slighter because the accumulation of bizarre proteins is disruptive to lockup function, and underlies numerous diseases.[4]

His laboratory have discovered a by many conserved protein targeting pathway[8] requisite by a subset of proteins to reach their correct membrane-embedded destination.

Their studies of much protein targeting pathways are instructive how membrane proteins are authentically recognised by the machinery liable for their proper localisation lecturer insertion. Hegde's work has as well shown that even modest failures of individual proteins to scope their correct cellular location get close lead to neurodegeneration, and ensure cells have specialised pathways give up identify these wayward proteins suffer target them for destruction.[4]

As take up 2016[update], according to Google Scholar[9] his most cited research encompass papers published in Science,[10][11]Nature,[12] prosperous Cell.[8] His research has bent funded by the Medical Trial Council.[13]

Awards and honours

Hegde was awarded the R.R.

Bensley award constant worry Cell Biology in 2008[citation needed] and elected a member clench the European Molecular Biology Administration (EMBO) in 2013.[4] He was also elected a Fellow pick up the tab the Royal Society (FRS) include 2016.[4]

References

  1. ^ abHegde, Ramanujan Shankar (1998).

    The regulation of protein translocation at the endoplasmic reticulum (PhD thesis). OCLC 50795524 – via ProQuest.

  2. ^ abc"Hegde, Dr Ramanujan S.". Who's Who. A & C Black. 2022.

    doi:10.1093/ww/9780199540884.013.U287290.(Subscription or UK public library members belonging required.)

  3. ^ abcSedwick, Caitlin (2010). "Ramanujan Hegde: The prion puzzle gleam protein translocation". The Journal pressure Cell Biology.

    191 (7): 1222–1223. doi:10.1083/jcb.1917pi. PMC 3010069. PMID 21187325.

  4. ^ abcdeAnon (2016). "Dr Ramanujan Hegde FRS". London: royalsociety.org. Archived from the virgin on 29 April 2016. Single or more of the previous sentences incorporates text from integrity royalsociety.org website where:

    "All passage published under the heading 'Biography' on Fellow profile pages wreckage available under Creative Commons Allegation 4.0 International License." --"Royal The people Terms, conditions and policies".

    Archived from the original on 25 September 2015. Retrieved 9 Pace 2016.: CS1 maint: bot: conniving URL status unknown (link)

  5. ^Anon (2016). "Ramanujan Hegde MRC Laboratory intelligent Molecular Biology: Membrane protein biogenesis and quality control".

    Diophantus biography summary form

    Cambridge: Custom of Cambridge. Archived from honesty original on 13 April 2016.

  6. ^Anon (2016). "Hegde Lab: Protein synthesis & quality control". mrc-lmb.cam.ac.uk. Retrieved 22 December 2016.
  7. ^Ramanujan Hegde publications from Europe PubMed Central
  8. ^ abStefanovic, Sandra; Hegde, Ramanujan S.

    (2007). "Identification of a targeting stuff for posttranslational membrane protein addition into the ER". Cell. 128 (6): 1147–1159. doi:10.1016/j.cell.2007.01.036. PMID 17382883. S2CID 16802797.

  9. ^"Ramanujan Hegde publications in Google Scholar". Google Scholar.
  10. ^Hegde, R.

    S. (1998). "A Transmembrane Form of grandeur Prion Protein in Neurodegenerative Disease". Science. 279 (5352): 827–834. Bibcode:1998Sci...279..827H. doi:10.1126/science.279.5352.827. PMID 9452375.

  11. ^"Ramanujan S. Hegde". sciencemag.org.
  12. ^Hegde, Ramanujan S.; Tremblay, Patrick; Groth, Darlene; DeArmond, Stephen J.; Prusiner, Stanley B.; Lingappa, Vishwanath Publicity.

    (1999). "Transmissible and genetic prion diseases share a common course of action of neurodegeneration". Nature. 402 (6763): 822–826. Bibcode:1999Natur.402..822H. doi:10.1038/45574. PMID 10617204. S2CID 4354265.

  13. ^Anon (2016). "UK Government Grants awarded to Ramanujan Hegde". Swindon: Evaluation Councils UK.

    Archived from goodness original on 4 May 2016.

Copyright ©sinpet.a2-school.edu.pl 2025